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Indications
ENBREL is indicated for reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be initiated in combination with methotrexate (MTX) or used alone. Read more

ENBREL is indicated for the treatment of patients 4 years or older with chronic moderate to severe plaque psoriasis (PsO) who are candidates for systemic therapy or phototherapy.

ENBREL is indicated for reducing signs and symptoms, inhibiting the progression of structural damage of active arthritis, and improving physical function in patients with psoriatic arthritis (PsA). ENBREL can be used with or without MTX.

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis in patients ages 2 and older. Close

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Watching an airplane take flight looks easy and smooth. It's actually a meticulous science based on accurate and consistent measurements. Combustors precisely regulate the fuel injection rate to help maintain a controlled and consistent propulsion during flight. Similarly, the self-injection process aims to bring a consistent and controlled experience. Our device engineers explored the operational components.

See what we discovered

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Striving for Consistency with the Self-Injection


Striving for consistency with the self-injection

Planes taking flight are designed to create a repeatable and reliable experience. With self-injection now a common practice for patients with diseases ranging from rheumatoid arthritis to diabetes, shouldn't these patients be able to rely on a consistent injection experience?

We looked at some common self-injection devices for insight into how they are designed for consistency and control.

Prefilled syringe administration

A Controlled Dose

Prefilled syringes

Unlike products that may require premixing or drawing the medication from a vial, the prefilled syringe comes ready with a consistent drug volume. This manual option gives patients control over the speed of needle insertion as well as medication extrusion.

As a healthcare professional, you may remember being trained to puncture the skin quickly using a dart-like motion to insert the needle for subcutaneous injections. Patients are oftentimes instructed to do the same while self-injecting.

Whether patients prefer it fast or slow, they have the control while self-administering.

Control while self-administering
Spring-loaded pen injector administration

Click of a Button

Spring-loaded pen injectors

Some spring-loaded pen injectors come prefilled and include a hidden needle. This can help to shorten preparation time of the medication prior to the injection.

Automated for consistency with the push of a button, many pen injectors use tension from a single spring to trigger both needle insertion and medication extrusion.

With this automated device, injection rate is determined by the spring’s tension rather than a user-controlled depression of the plunger.

Rate determined by spring’s tension
Electromechanical automation

Electromechanical Automation

This website is for informational purposes intended for healthcare professionals only. If you are not a healthcare professional, please contact your doctor about ENBREL. Patients should be trained by a healthcare professional prior to using the Enbrel Mini® cartridge with AutoTouch® autoinjector. Detailed instructions are provided in the Instructions for Use.

In November 2017, we introduced a different injection device. Our device engineers utilized electromechanical technology to create a final product that would ensure a consistent delivery time.

In order to create the level of automated control needed, the device was designed to house 2 distinct motors–one for each unique force needed while injecting.

The first motor ensures fast needle penetration and is similar to the fast darting motion used with a syringe, with a minimum needle insertion speed of 200 millimeters per second (mm/s).

The second motor allows patients to control plunger extrusion force to their comfort preference, with minimum drug delivery speeds of 6 mm/s, 5 mm/s, or 4 mm/s.

No matter which speed patients choose, they get a consistent delivery of ENBREL with 3 preset speeds.

Two distinct motors for needle insertion and medication extrusion

Enbrel Mini® cartridge with AutoTouch® autoinjector Innovative features designed with patient insights

In a usability study of 60 participants who practiced a simulated injection*
0% agreed or strongly agreed that they always felt in control of their injection from start to finish with Enbrel Mini® with AutoTouch®

*Enbrel Mini® with AutoTouch® Usability Study Design In a multicenter usability study, 60 participants—55 adult patients taking medication for RA, PsO, PsA, or AS, plus 5 caregivers—were asked to rate their agreement from 1 (strongly disagree) to 5 (strongly agree) with the statement "I always felt in control of my injection, from start to finish". Each interview introduced the product, provided IFU-based training, and provided time to review the device and labeling. Participants practiced a simulated injection with a prototype device and cartridge that did not contain needle or fluid. †RA—Rheumatoid Arthritis; PsO—Plaque Psoriasis; PsA—Psoriatic Arthritis; AS—Ankylosing Spondylitis; IFU—Instructions for Use.

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